"To know how to grow old is the master work of wisdom, and one of the most difficult chapters in the great art of living."
~Henri Frederic Amiel
Since 1906 when Alois Alzheimer noted “a severe disease of the cerebral cortex,” scientists have been trying to learn what causes what for many years was called “senile dementia.” As the population has grown older and the disease has increasingly taken its toll on seniors and their families, research has increased enormously.
According to the Alzheimer’s Association, 60-80% of dementia cases are caused by Alzheimer’s disease, a progressive illness with no known cure. Over six million Americans are living with the disease, with almost two-thirds of them women.
There is much still not known about our brains and how to treat illnesses that change our brains as we age. In July, the Food and Drug Administration gave full approval of the drug Leqembi, which reduces amyloid clumps in the brain that may cause Alzheimer’s.
“It is not a cure and does not restore memories ravaged by the fatal neurodegenerative disease, but many neurologists say having a drug that slows Alzheimer’s even modestly is a milestone after years of failed drug trials,” according to the Washington Post. Given intravenously every other week at a cost of $26,500 per year, this drug is not covered by Medicare.
Other research highlighted at last month’s Alzheimer’s Association International Conference included trials of Donanemab, a drug that helps remove amyloid plaques; blood tests to diagnose Alzheimer’s biomarkers; and the connection between gut health and the brain. Japanese researchers are working on a vaccine to reduce amyloid plaques.
The Center for Medicare & Medicaid Innovation recently announced a test model to improve dementia care management to improve quality of life for people with dementia, reduce strain on their unpaid caregivers, and enable them to remain in their homes. Participants will receive care coordination and care management, caregiver education and support, and respite services.
The Alzheimer’s Association is an excellent resource for information on aging and mental health. They list 10 warning signs as:
Outsmarting Alzheimer’s involves a lifestyle that is recommended for other health benefits as well: staying socially active, maintaining a diet rich in plant foods and low in highly processed foods, getting regular exercise for 15-30 minutes three times a week or more, reducing stress, and getting enough sleep. Risk factors include obesity, smoking, hypertension, and diabetes.
According to a recent article in Axios that draws on a study published in the journal Alzheimer’s & Dementia, Maryland has the highest estimated prevalence of Alzheimer’s Disease (AD) among residents over 65 — 12.9% — in the country. The authors of the study did not speculate as to why Maryland would have the highest prevalence of AD, but did state that the prevalence is highest in the east and southeast regions of the U.S.
County estimates of AD prevalence were also made in the study. The estimates for Eastern Shore counties are shown below.
Source: Khana, et.al., “Prevalence of Alzheimer’s disease dementia…,” July 17, 2023,
Alzheimer’s & Dementia
Muriel Cole has a Certificate in Gerontology from the University of Maryland and co-chairs the Kent County Commission on Aging. She lives in Chestertown.
Title image: Pond at Pickering Creek Audubon Center, Talbot Co. Photo: Jan Plotczyk